Elective neck dissection versus observation in early stage oral squamous cell carcinoma: recurrence and survival
김동욱, 이바다, 임정환, 박정현, 남웅, 김형준, 차인호,
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김동욱 ( Kim Dong-Wook ) - Yonsei University College of Dentistry Department of Oral and Maxillofacial Surgery
이바다 ( Lee Ba-Da ) - Yonsei University College of Dentistry Department of Oral and Maxillofacial Surgery
임정환 ( Lim Jung-Hwan ) - Yonsei University College of Dentistry Department of Oral and Maxillofacial Surgery
박정현 ( Park Jung-Hyun ) - Ewha Womans University Medical Center Department of Oral and Maxillofacial Surgery
남웅 ( Nam Woong ) - Yonsei University College of Dentistry Department of Oral and Maxillofacial Surgery
김형준 ( Kim Hyung-Jun ) - Yonsei University College of Dentistry Department of Oral and Maxillofacial Surgery
차인호 ( Cha In-Ho ) - Yonsei University College of Dentistry Department of Oral and Maxillofacial Surgery
KMID : 0355620160420060358
Abstract
Objectives: To evaluate the results of elective neck dissection versus those of observation in the treatment of early stage oral squamous cell carcinoma and to identify factors related to recurrence and survival.
Materials and Methods: This was a retrospective study of 52 patients who underwent elective neck dissection and 27 who did not receive neck dissection.
Results: In survival analyses, elective neck dissection showed a benefit in overall recurrence (P=0.027), especially in stage I patients (P=0.024). With regard to survival, the benefit was statistically insignificant (P=0.990). In multivariable analysis, overall recurrence was independently related to poor histologic grade (odds ratio [OR]=9.65, P=0.006), and cancer-specific death was independently related to advanced age (OR=6.3, P=0.022), higher clinical T stage (OR=15.2, P=0.01), and poorly differentiated histologic grade (OR=6.6, P=0.025).
Conclusion: Though there was lower recurrence in the elective neck dissection group, there were no statistically significant results on survival. The characteristics of the tumor itself, such as clinical T stage and poor histologic grade, may be more important in cancer-specific survival.
키워드
Oral cancer; Squamous cell carcinoma; Neck dissection; Survival analysis; Survival rate
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